MicroRNAs and Long Non-coding RNAs in Genetic Diseases.

ABSTRACT: Since the discovery and classification of non-coding RNAs, their roles have gained great attention. In this respect, microRNAs and long non-coding RNAs have been firmly demonstrated to be linked to regulation of gene expression and onset of human diseases, including rare genetic diseases; therefore they are suitable targets for therapeutic intervention. This issue, in the context of rare genetic diseases, is being considered by an increasing number of research groups and is of key interest to the health community. In the case of rare genetic diseases, the possibility of developing personalized therapy in precision medicine has attracted the attention of researchers and clinicians involved in developing "orphan medicinal products" and proposing these to the European Medicines Agency (EMA) a

SUBMITTER: Finotti A 

PROVIDER: S-EPMC6469593 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature