Modeling and predicting osteoarthritis progression: data from the osteoarthritis initiative.

ABSTRACT:

Objective

The goal of this study was to model the longitudinal progression of knee osteoarthritis (OA) and build a prognostic tool that uses data collected in 1 year to predict disease progression over 8 years.

Design

To model OA progression, we used a mixed-effects mixture model and 8-year data from the Osteoarthritis Initiative (OAI)-specifically, joint space width measurements from X-rays and pain scores from the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire. We included 1243 subjects who at enrollment were classified as being at high risk of developing OA based on age, body mass index (BMI), and medical and occupational histories. After clustering subjects based on radiographic and pain progression, we used clinical variables collec

SUBMITTER: Halilaj E 

PROVIDER: S-EPMC6469859 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature