An Integrated, High-Throughput Strategy for Multiomic Systems Level Analysis.

ABSTRACT: Proteomics, metabolomics, and transcriptomics generate comprehensive data sets, and current biocomputational capabilities allow their efficient integration for systems biology analysis. Published multiomics studies cover methodological advances as well as applications to biological questions. However, few studies have focused on the development of a high-throughput, unified sample preparation approach to complement high-throughput omic analytics. This report details the automation, benchmarking, and application of a strategy for transcriptomic, proteomic, and metabolomic analyses from a common sample. The approach, sample preparation for multi-omics technologies (SPOT), provides equivalent performance to typical individual omic preparation methods but greatly enhances throughput and minimi

SUBMITTER: Gutierrez DB 

PROVIDER: S-EPMC6469931 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature