The Suv420h histone methyltransferases regulate PPAR-γ and energy expenditure in response to environmental stimuli.

ABSTRACT: Obesity and its associated metabolic abnormalities have become a global emergency with considerable morbidity and mortality. Epidemiologic and animal model data suggest an epigenetic contribution to obesity. Nevertheless, the cellular and molecular mechanisms through which epigenetics contributes to the development of obesity remain to be elucidated. Suv420h1 and Suv420h2 are histone methyltransferases responsible for chromatin compaction and gene repression. Through in vivo, ex vivo, and in vitro studies, we found that Suv420h1 and Suv420h2 respond to environmental stimuli and regulate metabolism by down-regulating peroxisome proliferator-activated receptor gamma (PPAR-γ), a master transcriptional regulator of lipid storage and glucose metabolism. Accordingly, mice lacking Suv420h protein

SUBMITTER: Pedrotti S 

PROVIDER: S-EPMC6469946 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature