Translocator protein (TSPO) and stress cascades in mouse models of psychosis with inflammatory disturbances.

ABSTRACT: Changes in inflammatory cascades have been implicated in the underlying pathophysiology of psychosis. Translocator protein 18 kDa (TSPO) has been used to assess neuroinflammatory processes in psychotic disorders. Nonetheless, it is unclear whether TSPO, a mitochondrial protein, can be interpreted as a general marker for inflammation in diseases involving psychosis. To address this question, we investigated TSPO signaling in representative mouse models for psychosis with inflammatory disturbances. The maternal immune activation and cuprizone short-term exposure models show different TSPO signaling. Furthermore, we observed similarities and differences in their respective stress pathways including stress hormone signaling and oxidative stress that are functionally interconnected with the inf

SUBMITTER: Fukudome D 

PROVIDER: S-EPMC6470041 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature