Homeobox B13 G84E Mutation and Prostate Cancer Risk.

ABSTRACT:

Background

The homeobox B13 (HOXB13) G84E mutation has been recommended for use in genetic counselling for prostate cancer (PCa), but the magnitude of PCa risk conferred by this mutation is uncertain.

Objective

To obtain precise risk estimates for mutation carriers and information on how these vary by family history and other factors.

Design, setting, and participants

Two-fold: a systematic review and meta-analysis of published risk estimates, and a kin-cohort study comprising pedigree data on 11983 PCa patients enrolled during 1993-2014 from 189 UK hospitals and who had been genotyped for HOXB13 G84E.

Outcome measurements and statistical analysis

Relative and absolute PCa risks. Complex segregation analysis with ascertainment adjustment to derive age-specific

SUBMITTER: Nyberg T 

PROVIDER: S-EPMC6470122 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature