Enhanced discriminative aversive learning and amygdala responsivity in 5-HT transporter mutant mice.

ABSTRACT: Genetic variation in the human serotonin transporter (5-HTT) has been linked to altered fear learning but the data are inconsistent and the mechanism is unclear. The present study investigated conditioned aversive learning in 5-HTT knockout (KO) mice while simultaneously recording neural network activity (theta oscillations) and hemodynamic responses (tissue oxygen delivery) from the amygdala, a brain region necessary for forming fearful memories. Conditioned aversive learning was measured using a discrimination learning task in which one auditory cue was paired with foot-shock, whereas a second auditory cue was not. Compared with wild-type mice, 5-HTTKO mice exhibited faster discrimination learning. This effect was associated with stronger theta frequency oscillations and greater hemodyna

SUBMITTER: Lima J 

PROVIDER: S-EPMC6470159 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature