Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome.

ABSTRACT: Dravet syndrome (DS) is a catastrophic developmental and epileptic encephalopathy characterized by severe, pharmacoresistant seizures and the highest risk of Sudden Unexpected Death in Epilepsy (SUDEP) of all epilepsy syndromes. Here, we investigated the time course of maturation of neuronal GABAergic signaling in the Scn1b^-/- and Scn1a^+/- mouse models of DS. We found that GABAergic signaling remains immature in both DS models, with a depolarized reversal potential for GABA_A-evoked currents compared to wildtype in the third postnatal week. Treatment of Scn1b^-/- mice with bumetanide resulted in a delay in SUDEP onset compared to controls in a subset of mice, without prevention of seizure activity or amelioration of failure to thrive. We propose th

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC6470170 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature