Isoflurane-Induced Burst Suppression Increases Intrinsic Functional Connectivity of the Monkey Brain.

ABSTRACT: Animal functional magnetic resonance imaging (fMRI) has provided key insights into the physiological mechanisms underlying healthy and diseased brain states. In non-human primates, resting-state fMRI studies are commonly conducted under isoflurane anesthesia, where anesthetic concentration is used to roughly infer anesthesia depth. However, within the recommended isoflurane concentration range (1.00-1.50%), the brain state can switch from moderate anesthesia characterized by stable slow wave (SW) electroencephalogram (EEG) signals to deep anesthesia characterized by burst suppression (BS), which is electrophysiologically distinct from the resting state. To confirm the occurrence rate of BS activity in common setting of animal fMRI study, we conducted simultaneous resting-state EEG and fMRI

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC6470287 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature