Improvement of Colonic Immune Function with Soy Isoflavones in High-Fat Diet-Induced Obese Rats.

ABSTRACT: Background: The damage to intestinal barrier function plays an important role in the development of obesity and associated diseases. Soy isoflavones are effective natural active components for controlling obesity and reducing the level of blood lipid. Here, we explored whether these effects of soy isoflavones were associated with the intestinal barrier function. Methods and Results: The obese rat models were established by high fat diet feeding. Then, those obese rats were supplemented with soy isoflavones at different doses for 4 weeks. Our results showed that obesity induced the expressions of pro-inflammatory cytokines, decreased the anti-inflammatory cytokine (IL-10) expression, elevated intestinal permeability, altered gut microbiota and exacerbated oxidative damages in colon. The adm

SUBMITTER: Luo Q 

PROVIDER: S-EPMC6470843 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature