INOS Gene Ablation Prevents Liver Fibrosis in Leptin-Deficient ob/ob Mice.
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ABSTRACT:
SUBMITTER: Becerril S
PROVIDER: S-EPMC6470935 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
<i>iNOS</i> Gene Ablation Prevents Liver Fibrosis in Leptin-Deficient <i>ob/ob</i> Mice.
Becerril Sara S Rodríguez Amaia A Catalán Victoria V Ramírez Beatriz B Unamuno Xabier X Gómez-Ambrosi Javier J Frühbeck Gema G
Genes 20190227 3
<i>iNOS</i> deficiency in <i>ob/ob</i> mice improved liver inflammation and ECM remodeling-related genes, decreasing fibrosis, and metabolic dysfunction. The activation of iNOS by leptin is necessary for the synthesis and secretion of TNC in hepatocytes, suggesting an important role of this alarmin in the development of NAFLD. ...[more]
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