The Effect of Inulin on Lifespan, Related Gene Expression and Gut Microbiota in InR^p5545/TM3 Mutant Drosophila melanogaster: A Preliminary Study.

ABSTRACT: Inulin is considered an efficient prebiotic and is beneficial for metabolic diseases via promoting intestinal probiotic enrichment and the metabolites of short-chain fatty acids (SCFAs). However, the effect of inulin on patients with InR deficiencies has seldom been reported. In this study, the lifespan, related gene expression, and gut microbiota of InR^p5545/TM3 (insulin receptor mutant) Drosophila melanogaster under inulin treatment were investigated. The results showed that the lifespan was extended in only males and not in females. Furthermore, distinctly different patterns of gene expression were found between males and females, especially in the insulin/insulin-like growth factor (IGF)-like signalling (IIS) and target of rapamycin (TOR) pathways. Addit

SUBMITTER: Dong Y 

PROVIDER: S-EPMC6470987 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature