Membrane Sphingolipids Regulate the Fitness and Antifungal Protein Susceptibility of <i>Neurospora crassa</i>.

ABSTRACT: The membrane sphingolipid glucosylceramide (GlcCer) plays an important role in fungal fitness and adaptation to most diverse environments. Moreover, reported differences in the structure of GlcCer between fungi, plants and animals render this pathway a promising target for new generation therapeutics. Our knowledge about the GlcCer biosynthesis in fungi is mainly based on investigations of yeasts, whereas this pathway is less well characterized in molds. We therefore performed a detailed lipidomic profiling of GlcCer species present in Neurospora crassa and comprehensively show that the deletion of genes encoding enzymes involved in GlcCer biosynthesis affects growth, conidiation and stress response in this model fungus. Importantly, our study evidences that differences in the pathw

SUBMITTER: Huber A 

PROVIDER: S-EPMC6471014 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature