Genome Mining and Comparative Analysis of Streptococcus intermedius Causing Brain Abscess in a Child.

ABSTRACT: Streptococcus intermedius (SI) is associated with prolonged hospitalization and low survival rates. The genetic mechanisms involved in brain abscess development and genome evolution in comparison to other members of the Streptococcus anginosus group are understudied. We performed a whole-genome comparative analysis of an SI isolate, LAU_SINT, associated with brain abscess following sinusitis with all SI genomes in addition to S. constellatus and S. anginosus. Selective pressure on virulence factors, phages, pan-genome evolution and single-nucleotide polymorphism analysis were assessed. The structural details of the type seven secretion system (T7SS) was elucidated and compared with different organisms. ily and nanA were both abundant and conserved.

SUBMITTER: Issa E 

PROVIDER: S-EPMC6471051 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature