The PYY/Y2R-Deficient Mouse Responds Normally to High-Fat Diet and Gastric Bypass Surgery.

ABSTRACT:

Background/goals

The gut hormone peptide YY (PYY) secreted from intestinal L-cells has been implicated in the mechanisms of satiation via Y2-receptor (Y2R) signaling in the brain and periphery and is a major candidate for mediating the beneficial effects of bariatric surgery on appetite and body weight.

Methods

Here we assessed the role of Y2R signaling in the response to low- and high-fat diets and its role in the effects of Roux-en-Y gastric bypass (RYGB) surgery on body weight, body composition, food intake, energy expenditure and glucose handling, in global Y2R-deficient (Y2RKO) and wildtype (WT) mice made obese on high-fat diet.

Results

Both male and female Y2RKO mice responded normally to low- and high-fat diet in terms of body weight, body composition, fasting

SUBMITTER: Boland B 

PROVIDER: S-EPMC6471341 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature