The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity.

ABSTRACT: Human longevity is a complex phenotype resulting from the combinations of context-dependent gene-environment interactions that require analysis as a dynamic process in a cohesive ecological and evolutionary framework. Genome-wide association (GWAS) and whole-genome sequencing (WGS) studies on centenarians pointed toward the inclusion of the apolipoprotein E (APOE) polymorphisms ε2 and ε4, as implicated in the attainment of extreme longevity, which refers to their effect in age-related Alzheimer's disease (AD) and cardiovascular disease (CVD). In this case, the available literature on APOE and its involvement in longevity is described according to an anthropological and population genetics perspective. This aims to highlight the evolutionary history of this gene, how its parti

SUBMITTER: Abondio P 

PROVIDER: S-EPMC6471373 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature