Matrix Metalloproteinases in Pulmonary and Central Nervous System Tuberculosis-A Review.

ABSTRACT: Tuberculosis (TB) remains the single biggest infectious cause of death globally, claiming almost two million lives and causing disease in over 10 million individuals annually. Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes with various physiological roles implicated as key factors contributing to the spread of TB. They are involved in the breakdown of lung extracellular matrix and the consequent release of Mycobacterium tuberculosis bacilli into the airways. Evidence demonstrates that MMPs also play a role in central nervous system (CNS) tuberculosis, as they contribute to the breakdown of the blood brain barrier and are associated with poor outcome in adults with tuberculous meningitis (TBM). However, in pediatric TBM, data indicate that MMPs may play a role in both

SUBMITTER: Rohlwink UK 

PROVIDER: S-EPMC6471445 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature