Polyethylene Glycol: The Future of Posttraumatic Nerve Repair? Systemic Review.

ABSTRACT: Peripheral nerve injury is a common posttraumatic complication. The precise surgical repair of nerve lesion does not always guarantee satisfactory motor and sensory function recovery. Therefore, enhancement of the regeneration process is a subject of many research strategies. It is believed that polyethylene glycol (PEG) mediates axolemmal fusion, thus enabling the direct restoration of axon continuity. It also inhibits Wallerian degeneration and recovers nerve conduction. This systemic review, performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, describes and summarizes published studies on PEG treatment efficiency in various nerve injury types and repair techniques. Sixteen original experimental studies in animal models and on

SUBMITTER: Paskal AM 

PROVIDER: S-EPMC6471459 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature