Prenatal manganese and cord blood mitochondrial DNA copy number: Effect modification by maternal anemic status.

ABSTRACT:

Introduction

Manganese (Mn) is an essential nutrient but also a toxicant at high exposures, when it can induce oxidative stress (OS). Mn uptake is inversely correlated with iron status, therefore anemic individuals may be more susceptible to Mn overload induced-OS, which can manifest as changes in mitochondrial DNA copy number (mtDNA CN). Our objectives were to: 1) determine stage-specific associations of prenatal Mn exposure with cord blood MtDNA CN; and 2) investigate effect modification by maternal anemia, ferritin, and mean corpuscular volume (MCV).

Materials and methods

We measured whole blood Mn, hemoglobin, serum ferritin, and MCV in the 2nd and 3rd trimester, in maternal blood at birth, and in cord blood from a prospective birth cohort in Mexico City, Mexico (n = 485

SUBMITTER: Kupsco A 

PROVIDER: S-EPMC6471611 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature