Walking pathways with positive feedback loops reveal DNA methylation biomarkers of colorectal cancer.

ABSTRACT:

Background

The search for molecular biomarkers of early-onset colorectal cancer (CRC) is an important but still quite challenging and unsolved task. Detection of CpG methylation in human DNA obtained from blood or stool has been proposed as a promising approach to a noninvasive early diagnosis of CRC. Thousands of abnormally methylated CpG positions in CRC genomes are often located in non-coding parts of genes. Novel bioinformatic methods are thus urgently needed for multi-omics data analysis to reveal causative biomarkers with a potential driver role in early stages of cancer.

Methods

We have developed a method for finding potential causal relationships between epigenetic changes (DNA methylations) in gene regulatory regions that affect transcription factor binding sites (T

SUBMITTER: Kel A 

PROVIDER: S-EPMC6471696 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature