Metabolic and signalling network maps integration: application to cross-talk studies and omics data analysis in cancer.

ABSTRACT:

Background

The interplay between metabolic processes and signalling pathways remains poorly understood. Global, detailed and comprehensive reconstructions of human metabolism and signalling pathways exist in the form of molecular maps, but they have never been integrated together. We aim at filling in this gap by integrating of both signalling and metabolic pathways allowing a visual exploration of multi-level omics data and study of cross-regulatory circuits between these processes in health and in disease.

Results

We combined two comprehensive manually curated network maps. Atlas of Cancer Signalling Network (ACSN), containing mechanisms frequently implicated in cancer; and ReconMap 2.0, a comprehensive reconstruction of human metabolic network. We linked ACSN and ReconMap

SUBMITTER: Sompairac N 

PROVIDER: S-EPMC6471697 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature