Upconversion-mediated ZnFe₂O₄ nanoplatform for NIR-enhanced chemodynamic and photodynamic therapy.

ABSTRACT: ZnFe₂O₄, a semiconductor catalyst with high photocatalytic activity, is ultrasensitive to ultraviolet (UV) light and tumor H₂O₂ for producing reactive oxygen species (ROS). Thereby, ZnFe₂O₄ can be used for photodynamic therapy (PDT) from direct electron transfer and the newly defined chemodynamic therapy (CDT) from the Fenton reaction. However, UV light has confined applicability because of its high phototoxicity, low penetration, and speedy attenuation in the biotissue. Herein, an upconversion-mediated nanoplatform with a mesoporous ZnFe₂O₄ shell was developed for near-infrared (NIR) light enhanced CDT and PDT. The nanoplatform (denoted as Y-UCSZ) was comprised of upconversion nanoparticles (UCNPs), si

SUBMITTER: Dong S 

PROVIDER: S-EPMC6471739 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature