Role of NADPH oxidase-2 in the progression of the inflammatory response secondary to striatum excitotoxic damage.

ABSTRACT:

Background

During excitotoxic damage, neuronal death results from the increase in intracellular calcium, the induction of oxidative stress, and a subsequent inflammatory response. NADPH oxidases (NOX) are relevant sources of reactive oxygen species (ROS) during excitotoxic damage. NADPH oxidase-2 (NOX-2) has been particularly related to neuronal damage and death, as well as to the resolution of the subsequent inflammatory response. As ROS are crucial components of the regulation of inflammatory response, in this work, we evaluated the role of NOX-2 in the progression of inflammation resulting from glutamate-induced excitotoxic damage of the striatum in an in vivo model.

Methods

The striata of wild-type C57BL/6 J and NOX-2 KO mice (gp91^Cybbtm1Din/J) were stereotact

SUBMITTER: Hernandez-Espinosa DR 

PROVIDER: S-EPMC6471795 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature