Joint bioinformatics analysis of underlying potential functions of hsa-let-7b-5p and core genes in human glioma.

ABSTRACT:

Background

Glioma accounts for a large proportion of cancer, and an effective treatment for this disease is still lacking because of the absence of specific driver molecules. Current challenges in the treatment of glioma are the accurate and timely diagnosis of brain glioma and targeted treatment plans. To investigate the diagnostic biomarkers and prospective role of miRNAs in the tumorigenesis and progression of glioma, we analyzed the expression of miRNAs and key genes in glioma based on The Cancer Genome Atlas database.

Methods

Of the 701 cases that were downloaded, five were normal and 696 were glioma. Then, 1626 differentially expressed genes were identified, and 173 aberrantly expressed miRNAs were calculated by edgeR. GO and KEGG pathway enrichment analyses were perfo

SUBMITTER: Xi X 

PROVIDER: S-EPMC6471881 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature