In vivo assembly and trafficking of olfactory Ionotropic Receptors.

ABSTRACT:

Background

Ionotropic receptors (IRs) are a large, divergent subfamily of ionotropic glutamate receptors (iGluRs) that are expressed in diverse peripheral sensory neurons and function in olfaction, taste, hygrosensation and thermosensation. Analogous to the cell biological properties of their synaptic iGluR ancestors, IRs are thought to form heteromeric complexes that localise to the ciliated dendrites of sensory neurons. IR complexes are composed of selectively expressed 'tuning' receptors and one of two broadly expressed co-receptors (IR8a or IR25a). While the extracellular ligand-binding domain (LBD) of tuning IRs is likely to define the stimulus specificity of the complex, the role of this domain in co-receptors is unclear.

Results

We identify a sequence in the co-recept

SUBMITTER: Abuin L 

PROVIDER: S-EPMC6472016 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature