NR3C1 gene polymorphisms are associated with high-altitude pulmonary edema in Han Chinese.

ABSTRACT:

Background

High-altitude pulmonary edema (HAPE) is a life-threatening form of non-cardiogenic edema which occurs in unacclimatized individuals after rapid ascent to high altitude. NR3C1 gene encodes for glucocorticoid receptor (GR) which plays an important role in stress and inflammation. This study aimed to investigate the association of NR3C1 polymorphisms with the susceptibility to HAPE in Han Chinese.

Methods

The 30 SNPs in the NR3C1 gene were genotyped by the Sequenom MassARRAY SNP assay in 133 HAPE patients (HAPE-p) and 135 matched Han Chinese resistant to HAPE (HAPE-r). The genotypic and allele frequencies, odds ratios (ORs), and 95% confidence intervals (95% CIs) were calculated, respectively.

Results

The 12 SNPs showed a significant difference between the HAP

SUBMITTER: Yang Y 

PROVIDER: S-EPMC6472084 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature