DecompTumor2Sig: identification of mutational signatures active in individual tumors.

ABSTRACT:

Background

The somatic mutations found in a tumor have in most cases been caused by multiple mutational processes such as those related to extrinsic carcinogens like cigarette smoke, and those related to intrinsic processes like age-related spontaneous deamination of 5-methylcytosine. The effect of such mutational processes can be modeled by mutational signatures, of which two different conceptualizations exist: the model introduced by Alexandrov et al., Nature 500:415-421, 2013, and the model introduced by Shiraishi et al., PLoS Genetics 11(12):e1005657, 2015. The initial identification and definition of mutational signatures requires large sets of tumor samples.

Results

Here, we present decompTumor2Sig, an easy to use R package that can decompose an individual tumor genome

SUBMITTER: Kruger S 

PROVIDER: S-EPMC6472187 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature