Influenza a virus-triggered autophagy decreases the pluripotency of human-induced pluripotent stem cells.

ABSTRACT: Maternal influenza infection during pregnancy was reported multiple times as the possible cause of many defects and congenital anomalies. Apart from several cases of influenza-related miscarriage during various trimesters of pregnancy, some epidemiological data suggest a link between maternal influenza infection and genetic abnormalities in offspring. However, there are no reports yet describing how maternal influenza alters cellular pathways at early stages of development to result in congenital defects in the fetus. In the present study, using proteomic approaches, we utilized human-induced pluripotent stem cells (hiPSCs) for modeling intrablastocyst infection with influenza virus to not only investigate the vulnerability and responses of pluripotent stem cells to this virus but also to

SUBMITTER: Zahedi-Amiri A 

PROVIDER: S-EPMC6472374 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature