Prognostic significance of EIF4G1 in patients with pancreatic ductal adenocarcinoma.

ABSTRACT:

Background

Advances in genomics have greatly improved the survival rate in cancer patients. However, due to genetic heterogeneity, pancreatic ductal adenocarcinoma (PDAC) is still difficult to diagnose early, and its survival rate is extremely low. Therefore, we identified biomarkers that predict the prognosis of PDAC patients using independent cohort data.

Materials and methods

To develop a novel prognostic biomarker, we used the gene expression and clinical data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). Kaplan-Meier survival curve using median values of genes as cutoff showed that EIF4G1 was the only statistically significant gene in the 3 cohorts. We analyzed the prognostic significance of EIF4G1 using the time-dependent area under the curve (

SUBMITTER: Goh TS 

PROVIDER: S-EPMC6472433 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature