Genomic Evaluation of Multiparametric Magnetic Resonance Imaging-visible and -nonvisible Lesions in Clinically Localised Prostate Cancer.

ABSTRACT:

Background

The prostate cancer (PCa) diagnostic pathway is undergoing a radical change with the introduction of multiparametric magnetic resonance imaging (mpMRI), genomic testing, and different prostate biopsy techniques. It has been proposed that these tests should be used in a sequential manner to optimise risk stratification.

Objective

To characterise the genomic, epigenomic, and transcriptomic features of mpMRI-visible and -nonvisible PCa in clinically localised disease.

Design, setting, and participants

Multicore analysis of fresh prostate tissue sampled immediately after radical prostatectomy was performed for intermediate- to high-risk PCa.

Intervention

Low-pass whole-genome, exome, methylation, and transcriptome profiling of patient tissue cores taken

SUBMITTER: Parry MA 

PROVIDER: S-EPMC6472613 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature