Next generation physiologically based kinetic (NG-PBK) models in support of regulatory decision making.

ABSTRACT: The fields of toxicology and chemical risk assessment seek to reduce, and eventually replace, the use of animals for the prediction of toxicity in humans. In this context, physiologically based kinetic (PBK) modelling based on in vitro and in silico kinetic data has the potential to a play significant role in reducing animal testing, by providing a methodology capable of incorporating in vitro human data to facilitate the development of in vitro to in vivo extrapolation of hazard information. In the present article, we discuss the challenges in: 1) applying PBK modelling to support regulatory decision making under the toxicology and risk-assessment paradigm shift towards animal replacement; 2) constructing PBK models without in vivo animal kinetic

SUBMITTER: Paini A 

PROVIDER: S-EPMC6472623 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature