An information theoretic phase I-II design for molecularly targeted agents that does not require an assumption of monotonicity.

ABSTRACT: For many years phase I and phase II clinical trials have been conducted separately, but there has been a recent shift to combine these phases. Although a variety of phase I-II model-based designs for cytotoxic agents have been proposed in the literature, methods for molecularly targeted agents (TAs) are just starting to develop. The main challenge of the TA setting is the unknown dose-efficacy relationship that can have either an increasing, plateau or umbrella shape. To capture these, approaches with more parameters are needed or, alternatively, more orderings are required to account for the uncertainty in the dose-efficacy relationship. As a result, designs for more complex clinical trials, e.g. trials looking at schedules of a combination treatment involving TAs, have not been extensive

SUBMITTER: Mozgunov P 

PROVIDER: S-EPMC6472641 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature