The role of HLA-A*33:01 in patients with cholestatic hepatitis attributed to terbinafine.

ABSTRACT:

Background & aims

Terbinafine is an antifungal agent that has been associated with rare instances of hepatotoxicity. In this study we aimed to describe the presenting features and outcomes of patients with terbinafine hepatotoxicity and to investigate the role of human leukocyte antigen (HLA)-A*33:01.

Methods

Consecutive high causality cases of terbinafine hepatotoxicity enrolled into the Drug Induced Liver Injury Network were reviewed. DNA samples underwent high-resolution confirmatory HLA sequencing using the Ilumina MiSeq platform.

Results

All 15 patients with terbinafine hepatotoxicity were more than 40 years old (median = 57 years), 53% were female and the median latency to onset was 38 days (range 24 to 114 days). At the onset of drug-induced liver injury, 80% w

SUBMITTER: Fontana RJ 

PROVIDER: S-EPMC6472700 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature