RNA sequencing of intestinal mucosa reveals novel pathways functionally linked to celiac disease pathogenesis.

ABSTRACT:

Background & aims

The early steps in the pathophysiology of celiac disease (CD) leading to loss of tolerance to gluten are poorly described. Our aim was to use RNA sequencing of duodenal biopsies in patients with active CD, CD in remission, and non-CD controls to gain insight into CD pathophysiology, identify additional genetic signatures linked to CD, and possibly uncover targets for future therapeutic agents.

Methods

We performed whole transcriptome shotgun sequencing of intestinal biopsies in subjects with active and remission CD and non-CD controls. We also performed functional pathway analysis of differentially expressed genes to identify statistically significant pathways that are up or down regulated in subjects with active CD compared to remission CD.

Results

SUBMITTER: Leonard MM 

PROVIDER: S-EPMC6472737 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature