CCR2+ migratory macrophages with M1 status are the early-responders in the cornea of HSV-1 infected mice.

ABSTRACT: Complex interactions between HSV-1 and infiltrating immune cells play important roles in establishing localized, acute virus replication as well as chronic latent infection. The extent and duration of initial virus replication are the key determinants of subsequent pathologic inflammatory responses and therefore, the accumulation of immune cell populations at this time point is a key target for prevention. Therefore, we evaluated the role of various immune cell infiltrates between 1 h and 28 days post-infection (PI) using mice infected with virulent HSV-1 strain McKrae without corneal scarification. The effect of corneal scarification on immune cell infiltrates was also determined. We first determined the activation status and origin of macrophage infiltrates as early as 1 h PI. We found a

SUBMITTER: Lee DH 

PROVIDER: S-EPMC6472814 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature