Abnormal submaximal cardiopulmonary exercise parameters predict impaired peak exercise performance in sickle cell anemia patients.

ABSTRACT:

Purpose

Sickle cell anemia (SCA) patients frequently have many comorbidities, including diastolic dysfunction (DD) and exercise intolerance. SCA patients often cannot reach maximal effort on exercise testing; little is known regarding whether submaximal exercise parameters can predict abnormal maximal exercise results in SCA patients and if there are any possible associations with DD.

Methods

A prospective longitudinal study was performed in SCA patients. All patients had a resting cardiac MRI (CMR), cardiopulmonary exercise test (CPET) with cycle ergometry using a ramp protocol, and an echocardiogram. Exercise data were compared with age-, gender-, and size-matched normal controls.

Results

Compared with normal controls, the SCA group (n = 19) had lower mean max oxyge

SUBMITTER: Powell AW 

PROVIDER: S-EPMC6472963 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature