Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules.

ABSTRACT: Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy that is associated with repetitive head impacts or exposure to blast waves. First described as punch-drunk syndrome and dementia pugilistica in retired boxers^1-3, CTE has since been identified in former participants of other contact sports, ex-military personnel and after physical abuse^4-7. No disease-modifying therapies currently exist, and diagnosis requires an autopsy. CTE is defined by an abundance of hyperphosphorylated tau protein in neurons, astrocytes and cell processes around blood vessels^8,9. This, together with the accumulation of tau inclusions in cortical layers II and III, distinguishes CTE from Alzheimer's disease and other tauopathies^10,11. However, the morpho

SUBMITTER: Falcon B 

PROVIDER: S-EPMC6472968 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature