Bloodstream infections exacerbate incidence and severity of symptomatic glucocorticoid-induced osteonecrosis.

ABSTRACT:

Background

Osteonecrosis is a common toxicity associated with glucocorticoid (e.g., dexamethasone and prednisone) treatment of children with acute lymphoblastic leukemia (ALL), but risk factors are incompletely defined. Infections are also a common complication of ALL therapy. Lipopolysaccharide (LPS) is used experimentally to mimic infection-related systemic effects. To our knowledge, the contribution of systemic infections to the risk of glucocorticoid-induced osteonecrosis has not been investigated.

Procedure

Patients with ALL on St. Jude Total Therapy XV (n = 365) were assessed for documented bacteremia prior to development of osteonecrosis, which was confirmed by MRI, and graded using the National Cancer Institute's Common Terminology for Adverse Events (version 3.0). I

SUBMITTER: Finch ER 

PROVIDER: S-EPMC6472979 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature