Computational Modeling of Glucose Uptake in the Enterocyte.

ABSTRACT: Absorption of glucose across the epithelial cells of the small intestine is a key process in human nutrition and initiates signaling cascades that regulate metabolic homeostasis. Validated and predictive mathematical models of glucose transport in intestinal epithelial cells are essential for interpreting experimental data, generating hypotheses, and understanding the contributions of and interactions between transport pathways. Here we report on the development of such a model that, in contrast to existing models, incorporates mechanistic descriptions of all relevant transport proteins and is implemented in the CellML framework. The model is validated against experimental and simulation data from the literature. It is then used to elucidate the relative contributions of the sodium-glucose

SUBMITTER: Afshar N 

PROVIDER: S-EPMC6473069 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature