The Role of Muscle Perfusion in the Age-Associated Decline of Mitochondrial Function in Healthy Individuals.

ABSTRACT: Maximum oxidative capacity of skeletal muscle measured by in vivo phosphorus magnetic resonance spectroscopy (³¹P-MRS) declines with age, and negatively affects whole-body aerobic capacity. However, it remains unclear whether the loss of oxidative capacity is caused by reduced volume and function of mitochondria or limited substrate availability secondary to impaired muscle perfusion. Therefore, we sought to elucidate the role of muscle perfusion on the age-related decline of muscle oxidative capacity and ultimately whole-body aerobic capacity. Muscle oxidative capacity was assessed by ³¹P-MRS post-exercise phosphocreatine recovery time (τ_PCr), with higher τ_PCr reflecting lower oxidative capacity, in 75 healthy participants (48 men, 22-89

SUBMITTER: Adelnia F 

PROVIDER: S-EPMC6473080 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature