Adverse Event Circumstances and the Case of Drug Interactions.

ABSTRACT: Adverse events are a common and for the most part unavoidable consequence of therapeutic intervention. Nevertheless, available tomes of such data now provide us with an invaluable opportunity to study the relationship between human phenotype and drug-induced protein perturbations within a patient system. Deciphering the molecular basis of such adverse responses is not only paramount to the development of safer drugs but also presents a unique opportunity to dissect disease systems in search of novel response biomarkers, drug targets, and efficacious combination therapies. Inspired by the potential applications of this approach, we first examined adverse event circumstances reported in FAERS and then performed a molecular level interrogation of cancer patient adverse events to investigate t

SUBMITTER: Soldatos TG 

PROVIDER: S-EPMC6473808 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature