Do brain structural abnormalities differentiate separate forms of urgency urinary incontinence?

ABSTRACT:

Aims

Urgency urinary incontinence (UUI) is a major problem for seniors. The underlying mechanisms of disease and therapy are unknown. We sought structural brain abnormalities that might underlie the functional differences previously observed by functional Magnetic Resonance Imaging in UUI patients versus controls, or among UUI responders versus non-responders to therapy-and thereby reveal potential disease mechanisms and therapeutic targets.

Methods

Secondary study of a trial of biofeedback-assisted pelvic floor muscle training (BFB) in 60 women (>60 yrs) with UUI, plus 11 age-matched continent controls. Brain structural abnormalities were investigated using: (1) white-matter hyperintensities (WMH); (2) diffusion tensor imaging (DTI) to reveal white-matter pathways with impa

SUBMITTER: Clarkson BD 

PROVIDER: S-EPMC6473817 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature