Social Interaction Improved by Oxytocin in the Subclass of Autism with Comorbid Intellectual Disabilities.

ABSTRACT: Approximately half of all autism spectrum disorder (ASD) individuals suffer from comorbid intellectual disabilities. Furthermore, the prevalence of epilepsy has been estimated to be 46% of patients with low intelligence quotient. It is important to investigate the therapeutic benefits and adverse effects of any recently developed drugs for this proportion of individuals with the so-called Kanner type of ASD. Therefore, we investigated the therapeutic and/or adverse effects of intranasal oxytocin (OT) administration, especially in adolescents and adults with ASD and comorbid intellectual disability and epilepsy, with regard to core symptoms of social deficits. We have already reported three randomized placebo-controlled trials (RCTs). However, we revisit results in our pilot studies from th

SUBMITTER: Higashida H 

PROVIDER: S-EPMC6473850 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature