Potential Utility of ¹²³I-MIBG Scintigraphy as a Predictor of Falls in Parkinson's Disease.

ABSTRACT: Background: Falls are associated with poor prognosis in patients with Parkinson's disease (PD). Although several factors related to falls were reported in patients with PD, objective predictors of falls are not identified. We aimed to determine whether ¹²³I-meta-iodobenzylguanidine (MIBG) cardiac scintigraphy could be a useful biomarker to predict falls. Methods: Forty-five patients with PD were enrolled in this study. These subjects were followed up more than 5 years after MIBG scintigraphy and were divided into two groups: one with decreased uptake of MIBG and the other without decreased uptake of MIBG. The cut-off value for the delayed heart-to-mediastinum ratio was 1.8. Kaplan-Meier analysis and a log-rank test were performed to test the predictive power of MIB

SUBMITTER: Murakami N 

PROVIDER: S-EPMC6473994 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature