Identification and characterization of Pv50, a novel Plasmodium vivax merozoite surface protein.

ABSTRACT:

Background

Plasmodium vivax contains approximately 5400 coding genes, more than 40% of which code for hypothetical proteins that have not been functionally characterized. In a previous preliminary screening using pooled serum samples, numerous hypothetical proteins were selected from among those that were highly transcribed in the schizont-stage of parasites, and highly antigenic P. vivax candidates including hypothetical proteins were identified. However, their immunological and functional activities in P. vivax remain unclear. From these candidates, we investigated a P. vivax 50-kDa protein (Pv50, PVX_087140) containing a highly conserved signal peptide that shows high transcription levels in blood-stage parasites.

Results

Recombinant Pv50 was expressed in a cell-free expr

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC6474066 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature