Cell lines and immune classification of glioblastoma define patient's prognosis.

ABSTRACT:

Background

Prognostic markers for glioblastoma are lacking. Both intrinsic tumour characteristics and microenvironment could influence cancer prognostic. The aim of our study was to generate a pure glioblastoma cell lines and immune classification in order to decipher the respective role of glioblastoma cell and microenvironment on prognosis.

Methods

We worked on two large cohorts of patients suffering from glioblastoma (TCGA, n = 481 and Rembrandt, n = 180) for which clinical data, transcriptomic profiles and outcome were recorded. Transcriptomic profiles of 129 pure glioblastoma cell lines were clustered to generate a glioblastoma cell lines classification. Presence of subtypes of glioblastoma cell lines and immune cells was determined using deconvolution.

Results

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SUBMITTER: Klopfenstein Q 

PROVIDER: S-EPMC6474266 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature