Risk factors for gestational diabetes: An umbrella review of meta-analyses of observational studies.

ABSTRACT:

Background/objective

Gestational diabetes mellitus (GDM) is a common pregnancy complication, with complex disease mechanisms, and several risk factors may contribute to its onset. We performed an umbrella review to summarize the evidence from meta-analyses of observational studies on risk factors associated with GDM, evaluate whether there are indications of biases in this literature and identify which of the previously reported associations are supported by convincing evidence.

Methods

We searched PubMed and ISI Web of Science from inception to December 2018 to identify meta-analyses examining associations between putative risk factors for GDM. For each meta-analysis we estimated the summary effect size, the 95% confidence interval, the 95% prediction interval, the between-

SUBMITTER: Giannakou K 

PROVIDER: S-EPMC6474596 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature