Microsatellite instability is inversely associated with type 2 diabetes mellitus in colorectal cancer.

ABSTRACT:

Background

Microsatellite instability (MSI) is a clonal change in the number of repeated DNA nucleotide units in microsatellites. High-frequency MSI (MSI-H) colorectal cancers (CRCs) are known to have different clinicopathological features compared with microsatellite stable (MSS) CRCs. In addition, previous studies have shown that type2 diabetes mellitus (T2DM) is a risk factor for malignant tumors including CRCs. The aim of this study was to investigate the relationship between T2DM and MSI-H colorectal cancer.

Methods

The study design is a single center, cross-sectional study. Data from a series of 936 patients with CRCs were collected and MSI status was assessed.

Results

In total, 29 (3.1%) and 907 (96.9%) tumors were classified as having MSI-H and low-frequency m

SUBMITTER: Nakayama Y 

PROVIDER: S-EPMC6474599 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature