A coarse-grained red blood cell membrane model to study stomatocyte-discocyte-echinocyte morphologies.

ABSTRACT: An improved red blood cell (RBC) membrane model is developed based on the bilayer coupling model (BCM) to accurately predict the complete sequence of stomatocyte-discocyte-echinocyte (SDE) transformation of a RBC. The coarse-grained (CG)-RBC membrane model is proposed to predict the minimum energy configuration of the RBC from the competition between lipid-bilayer bending resistance and cytoskeletal shear resistance under given reference constraints. In addition to the conventional membrane surface area, cell volume and bilayer-leaflet-area-difference constraints, a new constraint: total-membrane-curvature is proposed in the model to better predict RBC shapes in agreement with experimental observations. A quantitative evaluation of several cellular measurements including length, thickness

SUBMITTER: Geekiyanage NM 

PROVIDER: S-EPMC6474605 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature