Human retinoic acid-regulated CD161⁺ regulatory T cells support wound repair in intestinal mucosa.

ABSTRACT: Repair of tissue damaged during inflammatory processes is key to the return of local homeostasis and restoration of epithelial integrity. Here we describe CD161⁺ regulatory T (T_reg) cells as a distinct, highly suppressive population of T_reg cells that mediate wound healing. These T_reg cells were enriched in intestinal lamina propria, particularly in Crohn's disease. CD161⁺ T_reg cells had an all-trans retinoic acid (ATRA)-regulated gene signature, and CD161 expression on T_reg cells was induced by ATRA, which directly regulated the CD161 gene. CD161 was co-stimulatory, and ligation with the T cell antigen receptor induced cytokines that accelerated the wound healing of intestinal epithelial cells. We identified a tr

SUBMITTER: Povoleri GAM 

PROVIDER: S-EPMC6474659 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature